Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4
نویسندگان
چکیده
منابع مشابه
Nox4, the Good NADPH Oxidase!
NADPH oxidases of the Nox family are enzymes whose only known function is the production of reactive oxygen species (ROS). Since the first report on a vascular NADPH oxidase by Griendling et al in 1994,1 several thousand publications have been devoted to this topic. The general impression is that under physiological conditions, Nox proteins contribute to vascular signaling, whereas the overacti...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2018
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2017.12.023